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TRALA trial

In this study, researchers are looking to find a new way to treat amyloidosis, a condition that some people with myeloma develop. The aim is to find ways to treat the condition with fewer and less severe side effects

The context

Amyloidosis is a condition where the bone marrow makes abnormal blood cells called plasma cells and these cells produce a protein called amyloid. Amyloid can build up in tissues around the body which can affect the way organs work.

The project

This study is for people who have a type of amyloidosis called ‘systemic amyloid light-chain (AL) amyloidosis’, a condition that some people with myeloma can develop. Chemotherapy or high dose chemotherapy and a stem cell transplant are usually given to treat AL amyloidosis. Although this approach is successful, many people develop serious side effects from their treatment, such as infections and bleeding from the gut. In this study, researchers want to look at using targeted radiotherapy instead of high dose chemotherapy. Radiotherapy can be directed at the bone marrow, which destroys the abnormal cells leaving healthy cells relatively untouched. Delivering treatment in this more targeted way may alleviate the side effects seen from current treatment.

The aims

  • See how safe it is to use targeted radiotherapy as part of a stem cell transplant
  • Learn more about the side effects • See how well it works