20 results found.
Reapplying the brakes in out of control CLL cells
Chronic lymphocytic leukaemia typically responds well to chemotherapy and other treatments, but eventually these treatments can stop working. Dr Michie is investigating ways we can overcome this problem.
Monitoring the progression of aggressive blood cancers and finding new ways to stop them
Dr Andrejs Braun is studying a protein that he thinks may help to predict how aggressive certain types of blood cancer will be. They want to understand how and why this protein can influence the outcome of blood cancer.
Can MPN be cured?
People with myeloproliferative neoplasms require ongoing treatment to manage the disease which can cause severe side effects. Professor Tony Whetton is trying to create new treatments for this disease.
Attacking the roots of AML
In some cases of AML, people can see their disease return. This is because some cells get left behind despite treatment. Professor Bertie Göttgens wants to understand more about this and find new ways to treat the disease.
Why do CLL cells behave differently in different parts of the body?
Sometimes CLL can move from the bloodstream into the lymph nodes where the disease become much harder to treat. Professor Chris Pepper wants to understand how CLL cells change when they enter the lymph nodes to find new ways to treat the disease.
Three pronged attack: Reducing bone disease, anaemia and sending myeloma cells back to sleep
Professor Claire Edwards is trying to understand how myeloma cells and other cells in the bone communicate. She hopes that understanding this will pave the way to develop new treatments for the disease.
How do blood stem cells make decisions and how does this go wrong in leukaemia?
Dr David Kent is studying blood stem cells, a type of cell which has the potential of turning into many different types of blood cell. He wants to understand how this process goes wrong in leukaemia to try and find new ways to treat the disease.
Targeting AML that’s not responding to treatment
Some changes in genes can make diseases like AML more difficult to treat. Professor Elaine Dzierzak is studying one of these changes in the hope of being able to find new ways to treat the disease.
Understanding how lymphoma cells hide from the immune system
Dr Francesco Forcini is studying a tag found on some lymphoma cells that may stop the immune system from attacking them. The team will see whether targeting these tags could make lymphoma treatments kinder and more effective.
Analysing MDS stem cells to develop new treatments
Professor Jacqueline Boultwood is studying MDS stem cells, the cells at the root cause of the disease. The team hope to identify changes in these cells that could be targeted by drugs, giving people with the disease the best chance of survival.
Taking back control of healthy blood production
Special proteins in our cells control our genes by turning them on and off. When this process goes wrong, it can cause cells to grow uncontrollably and turn cancerous. Professor Jon Frampton wants to understand more about this.
Finding ways to target the roots of AML
Researchers want to develop new treatments which target cancerous blood stem cells, cells which are responsible for making many blood cells in the body. Professor Kamil Kranc wants to learn more about how we can prevent blood stem cells from turning cancerous.
How does leukaemia develop in babies?
Some babies develop leukaemia’s as a result of changes that happen before birth. Professor Katrin Ottersbach wants to understand more about these changes and why some babies see their cancer return despite treatment.
Developing a risk score for graft-versus host disease in stem cell transplants
Graft versus host disease is a dangerous complication of stem or bone marrow transplant. Professor Paul Moss wants to understand more about the disease so we predict who might develop it.
Understanding which immune cells make GvHD aggressive and resistant to treatment
Graft versus host disease is a dangerous complication of stem or bone marrow transplant. In this project, Professor Ronjon Chakraverty wants to understand more about why this develops and what can be done to stop it.
Improving how we manage acute leukaemia in pregnancy
When people develop acute leukaemia’s during pregnancy, there is a need to treat the mother whilst minimising harm to the unborn baby. Dr Sahra Ali is putting together guidelines to help clinicians make decisions, giving everyone the best chances of survival.
Making CAR-T therapy available to more people
CAR-T cell therapy is an exciting new therapy but can currently only be used for some cancer. Professor Waseem Qasim wants to create a more universal CAR-T cell therapy so more people can benefit from this treatment.
Do bacterial infections make MDS and AML worse?
Some people with blood cancer can develop severe and sometimes life-threatening infections. Professor Bunce is investigating whether these infections make the cancer worse, and whether we can stop this from happening.
Identifying the driving forces behind myelofibrosis
Professor Adam Mead wants to find a new way to tackle myelofibrosis. They are studying a specific gene that they think might be responsible for the disease.
Finding the weakness in AML’s armour
Chemotherapy is the main treatment for acute myeloid leukaemia currently which can cause harsh side effects. Professor Richard Darley is trying to find a way to create more targeted therapies with fewer side effects, to improve the quality of life for people with the disease.