72 results found.
Peripheral T-cell lymphoma (PTCL) is an aggressive and difficult to treat type of non-Hodgkin lymphoma. Some people with PTCL don’t respond to standard treatment which is often chemotherapy, and people can see their disease return. Researchers are trialing a new treatment aiming to help these people.
This trial is looking at treatment for children and young people who have Hodgkin lymphoma. Thanks to research current treatment methods are highly successful but can have long-term side effects. The aim of this trial is to find a way to reduce the long-term side effects of treatment and reduce the risk of the cancer coming back.
This trial is for people who have developed post-transplant lymphoproliferative disorders (PTLD) following a stem cell transplant. Current treatment methods do not work for everyone and researchers are trialling a new treatment aiming to help these people.
Understanding how CML turns into an aggressive disease
In some cases, chronic myeloid leukaemia (CML) can develop into an aggressive disease which can be difficult to treat. Dr Gillian Horne wants to understand more about this to work out how we can treat the disease when it becomes more aggressive.
Understanding the causes of post-transplant lymphoproliferative disease
PTLD is a blood cancer people can develop following stem cell transplant. It can be very difficult to treat and we urgently need to understand more about the disease so we can find better ways to treat it.
Improving outcomes for people with MDS
In this trial, the team want to test two new treatments in people with MDS to see if they can improve symptoms and overall quality of life.
Understanding how a virus can cause lymphoma
It’s thought that the Epstein-Barr virus is responsible for the development of many types of lymphoma. However, it’s not fully understood how the virus causes these diseases. Professor Michelle West will study this, with the hope of finding new ways to treat the disease.
Understanding how leukaemia develops in children with Down’s syndrome
In this study Professor Vyas will study how a genetic change some children with Down’s syndrome are born with, can cause leukaemia, and the steps involved in between.
Understanding changes in AML stem cells
Acute myeloid leukaemia (AML) is a fast growing and aggressive type of blood cancer. Professor Bonifer and her team want to learn more about alterations in genes of AML cells to find new ways to treat it.
Improving outcomes for people with MDS/MPN Overlap Syndromes
People with MDS/MPN Overlap Syndromes have very few treatment options available to them. This study will trial a new drug to see if it can extend and improve the lives of people with this disease.
Finding new ways to treat aggressive chronic myeloid leukaemia
Chronic myeloid leukaemia can sometimes stop responding to certain treatments and occasionally it can become a very aggressive disease. In this project, the team want to understand how we can tackle this.
Improving treatment for people with lymphoma
Dr Okosun and her team want to understand how changes in the coating of our DNA can lead to lymphomas and want to find ways to target treatments towards this.
Reducing the risk of developing blood cancer in children with Shwachman-Diamond syndrome
In this project, Professor Alan Warren and his team want to find new treatments for people with a disorder called Schwachman-Diamond syndrome.
Understanding whether we can prevent acute myeloid leukaemia
In this study, the team want to understand whether it is possible to prevent people from developing acute myeloid leukaemia.
Reducing the need for chemotherapy in people with acute myeloid leukaemia
In this project, Dr Dillon will look for markers in DNA that will tell clinicians if someone with AML is likely respond to a drug called venetoclax.
Using the immune system to improve treatment for people with myeloma
Myeloma is a blood cancer that is difficult to treat and we need to find new approaches to treat it. In this project, researchers will look at how we can use our immune system to do this.
Understand how MALT lymphoma develops
In this project, Professor Du will try and work out how MALT lymphoma develops to try and find new ways to treat it.
Ensuring people with ALL get the most appropriate level of treatment
In this project, Professor Moorman is trying to find markers that can tell clinicians how much treatment someone with ALL needs.
Finding new ways to treat MPN
In this project, Dr Mishto wants to understand whether we might be able to harness our immune system to treat MPN.
Understanding how chemotherapy impacts quality of life in people with MDS
This project is aimed at improving the quality of life for people with MDS.